The comments were welcomed by serenades of "Death to America" from the group at a function in Tehran to stamp the end of the Muslim fasting month of Ramazan.
While such hardline talk is commonplace - the US and Iran disjoined conciliatory ties the year after the Islamic unrest of 1979 - the incomparable pioneer's words highlighted the sharp contrasts in the middle of Iran and the West over the various clashes grasping the Center East notwithstanding Tuesday's noteworthy atomic arrangement.
"Our arrangements toward the egotistical US government won't change. US strategies in the locale vary from Iran's by 180 degrees," he said.
The arrangement in the middle of Iran and six forces drove by the United States has raised recommendations it may prepare for more noteworthy participation from Tehran on different issues, especially the war against the Islamic State assemble in Iraq and Syria.
Khamenei did not decide out that plausibility, taking note of there can be "remarkable circumstances" that legitimize talks, for example, the atomic issue, however demanded there would be no more extensive armistice.
"We haven't some other chats with the US on provincial and reciprocal issues," he said.
Tehran and Washington had casual examinations in 2001 when US troops attacked Afghanistan to remove the Taliban from force after the September 11 assaults.
Khamenei, who has the last say on all matters of state, has said over and again that Iran's engagement with the forces was exclusively to achieve an atomic arrangement that was to its greatest advantage.
He told admirers that the understanding would not change Iran's backing for the legislatures of Syria and Iraq nor its sponsorship of "mistreated individuals" in Yemen and Bahrain, and the Palestinians.
The US, conversely, he said, had upheld Israeli "outrages" in Gaza a year ago.
"In what capacity would we be able to arrange and concur with such strategies?" Khamenei inquired.
Iran has given cash and military counselors to bolster President Bashar al-Assad's administration in Syria against renegades it blames Bay Middle Easterner states for outfitting with Western connivance.