The couple made the declaration with a post on Mr Zuckerberg's Facebook page.
"Priscilla and I make them energize news:
we're expecting an infant young lady!" he kept in touch with his 33 million devotees.
In his post, the 31-year-old uncovered that they had endured three premature deliveries beforehand, however included that the danger of losing at this phase of the pregnancy was low.
He said that they had chosen to share the experience to help other people in a comparable circumstance.
"We trust that sharing our experience will give more individuals the same trust we felt and will help more individuals feel good sharing their stories.
"A great many people don't talk about unsuccessful labors in light of the fact that you stress your issues will separate you or reflect upon you - as though you're damaged or did something to precipitate this. So you battle all alone."
The Facebook author likewise referenced the mainstream "like" element on the informal organization.
"In our ultrasound, she even offered me a go-ahead "like" with her hand, so I'm now persuaded she takes after me," he composed.
The post did not say when the infant was expected.